Identification of Tumor HIstory at the Clone level
IdenTHic will develop a statistical framework to construct tumor evolution history from panel-sequencing and marker data that can be used to monitor patient and identify key genetic features.
The project will develop tumor deconvolution model-based methods specific to panel-sequencing from which clonal composition can be inferred. It will then estimate plausible tumor evolution histories at the clone level through phylogenetic scenarios that integrate population size information from marker data, and develop a phylogenetic-based differential expression model where samples are mixtures of sub-populations compared at different time-points of the phylogeny. This model will allow to select the most likely tumor evolution history through model selection approaches. All aspects of the project will share the global objective of identifying driver events in the tumor evolution that can influence prognosis and resistance to treatment, hence being of direct use to help practitioner decide on treatment allocation. Models will be tested and applied on data of Multiple Myeloma patient cohorts, and implemented in a shiny R-package.
Events
- 5 May 2025: Meeting at CRCT, Toulouse.
Program:
10am – 11am Round table of introduction
11am – 12pm Jill Corre: current questions in Myeloma
12pm-12:30pm Laure Buisson: panel sequencing data
12:30pm – 2pm Lunch (not provided)
2pm-3pm Alice Cleynen, Sophie Lèbre: statistical methods for deconvolution
Participants:
Laure Buisson, Alice Cleynen, Jill Corre, Sophie Lèbre, Thomas Minotto, Nicolas Noirault, Nikolay Shirokikh
- 11 April 2025: Meeting at IMAG, Montpellier
Program:
10am – 11am Round table of introduction
11am – 11:45am Thomas Minotto: presentation of postdoctoral projects
11:45 – 12:30pm Paul Bastide and Gilles Didier: presentation of PhD project
12:30pm – 2pm Lunch (not provided)
Participants:
Paul Bastide, Alice Cleynen, Gilles Didier, Stéphane Guindon, Sophie Lèbre, Thomas Minotto, Nicolas Noirault, Jean Peyhardi, Nikolay Shirokikh
- 20 November 2024: Workshop at IMAG, Montpellier
Cancer, évolution cellulaire et phylogénie
Program:
9h30 – 10h20 : Gilles Didier et Paul Bastide
Méthodes phylogénétiques pour l’étude de données de séquençage bulk
10h20 – 11h15 : Stéphane Guindon
Modélisation et algorithmes pour l’inférence statistique en phylogénie moléculaire
11h15 – 11h35 : Pause café
11h35 – 12h30 : Frédéric Thomas
Évolution et cancer.